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强力霉素的作用功效及合理应用

发布时间：

2022-02-15

强力霉素为四环素类抗菌药，其抗菌活性是土霉素的十倍以上。但是它的稳定性不好，见光、遇热....

强力霉素为四环素类抗菌药，其抗菌活性是土霉素的十倍以上。但是它的稳定性不好，见光、遇热容易发生水解、氧化、异构化及其它化学反应；遇见镁、钙、锌、铁、钡、锰、铝等金属离子，容易发生络合、螯合反应，形成难溶于水、活性差的盐。

它在水溶液中的pH值显较强的酸性，其1%的水溶液pH值为2-3，它水溶液中的酸性较强，不宜与碱性药物一起混合给畜禽饮水或注射使用。强力霉素给予畜禽口服安全剂量范围非常宽，其在兽医临床使用几十年的不良反应监测表明其对动物非常安全。

强力霉素饮水给药，动物口服后吸收迅速、自有生物利用度很高，在机体内的药物分布容积很大。强力霉素被动物吸收后，在动物的肺脏、气管和支气管、气管分泌物、脓液、唾液、关节液、肠组织、胸水、腹水等都有广泛、有效分布。

强力霉素(Doxycycline,Dox)作为一种传统的四环素类抗生素,它主要是通过穿透细胞膜与30S核糖体亚基结合，干扰细菌tRNA/mRNA相互作用，最终抑制细菌蛋白质合成而起抗菌作用。

近年来研究显示，强力霉素还具有许多其它非抗生素的生物学效应。

它可以部分通过MAPK途径保护MTECl(thymic medullary-type epithelial cell line1)抵抗MMC诱导的细胞凋亡，促进小鼠胸腺上皮细胞系(MTEC1)的增殖；同时，它也可以通过NF-κB和MAPK途径促进MTEC1分泌IL-6和GM-CSF。

而胸腺上皮细胞又可以促进胸腺细胞的发育、分化，因此强力霉素在临床治疗中，对疾病造成的细胞免疫系统的损伤有促进修复与重建作用。因此，强力霉素除了具有广谱抗菌、抗支原体作用，还具有非抗生素的提升免疫力之作用。

冬天来了，病毒肆虐造成的畜禽免疫系统损伤，在选用抗病毒药抑制、杀灭病毒的同时，强力霉素是个不错的配伍成分。比配伍其它的抗生素，使临床兽医开具的治疗处方，体现不一样的治疗效果。

强力霉素是不是什么病都治疗，什么时候用效果最好；下面就简单解析下四环素的使用，比较常见的就是强力霉素土霉素。

1、简单概括就是“二菌，四体，一虫灵”

2、二菌就是细菌跟放线菌，不部分的细菌病强力霉素效果都不错，所以经常用来搭配治疗呼吸道疾病；

3、四体说的是支原体（喘气病，咳嗽，我们经常会搭配使用强力霉素）；衣原体（母猪流产，小猪死亡率高，土霉素打小猪效果是不错的），螺旋体（包括痢疾等效果是有的，但是大部分大家使用痢菌净），立克次氏体（介于细菌病毒之间，本病就比较少了）

4、一虫指的是血液原虫，比如阿米巴原虫，附红细胞体等都属于血液原虫病。

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